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Despite the functional discovery of vitamin K reductase over eight decades ago, its identity remained elusive. Patients overdosed on warfarin can be rescued by administering high doses of vitamin K because of the existence of a warfarin-resistant vitamin K reductase. Warfarin, a vitamin K antagonist, is the most commonly prescribed oral anticoagulant. Taking too much can lead to severe bleeding.Vitamin K is a vital micronutrient implicated in a variety of human diseases. When you don’t take enough, the medication won’t be as effective. What happens if you take too much blood thinners?īlood thinners must be taken exactly as directed. Some natural health products and other medicines can make warfarin work too well. Many things can affect the way warfarin works. What happens when Coumadin levels are too high?Ī value higher than 3.5 increases the risk of bleeding problems. Example: Your patient has been taking warfarin 5mg daily for more than 2 weeks and INR is 1.8. What do I do if I take too much warfarin? How do you adjust warfarin if INR is too high?Ī nice “rule of thumb” for dose adjustments near the target range (generally works for INRs from the high 1s to low 4s): If you want to change the INR by 0.5-1 unit, increase or decrease the weekly dose by a daily dose. Vitamin K is the reversal agent for warfarin, and FDA recently approved the first reversal agent for the class of “new anticoagulant drugs,” Praxbind (idrucizumab). Reversal agents are used to counter the effects of anticoagulants in life-threatening situations of uncontrolled bleeding. Do not treat prophylactically-wait for the evidence of anticoagulation (elevated PT).If the PT is elevated, give phytonadione (vitamin K1), 10–25 mg orally, and increase the dose as needed to restore the PT to normal.Call your doctor or local poison control center or go to the nearest emergency room. If you think you’ve taken too much of this drug, act right away. If you take too much: Taking too much warfarin can lead to life-threatening bleeding. What should you do if you take too much warfarin? Or it may be used in combination with some of the other treatments. Vitamin K will slowly lower the INR, so this is a good option if the bleeding isn’t serious. Vitamin K can be given by mouth or as an injection. What is the antidote for a INR that is too high? There are several methods with which to reverse the anticoagulant effect of warfarin, including the omission of a dose of warfarin, administration of an oral or intravenous dose of vitamin K, use of fresh frozen plasma (FFP), Three- or Four-Factor Prothrombin Complex Concentrate (3F PCC, 4F PCC), recombinant Factor …